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Bioinformatics Laboratory
Medical Bioinformatics and e-Bioscience
Department of Clinical Epidemiology,
Biostatistics and Bioinformatics
Academic Medical Center


University of Amsterdam

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Systems Genomics People
High-throughput experimental methods in molecular biology provide the quantitative basis for gaining a better understanding of human disease. However, multifactorial diseases such as diabetes and atherosclerosis are complex disorders involving hundreds of genes and many developmental and environmental factors. Therefore, computational methods are needed that can uncover the molecular networks perturbed by disease. In the Systems Genomics group our goal is to develop such methods and tools. We focus on the

  1. construction of disease-specific microarray compendia for the integration of multiple gene expression studies (diabetes, breast cancer)
  2. comparison and consensus reconstruction of human metabolic pathway databases
  3. development of methods for investigating similarities and differences between model organisms and human using omics data and disease-specific functional networks.

The Systems Genomics research is led by Perry Moerland . Miranda Stobbe is a PhD student working on the comparison of public metabolic pathway databases. Umesh Nandal is a PhD student working on the comparison of model systems with human. Herman Sontrop is a PhD student at Philps Research working on compendium analyses of microarray breast cancer datasets.
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Topic revision: r7 - 2010-01-28 - 20:49:54 - PerryMoerland