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Bioinformatics Laboratory Medical Bioinformatics and e-Bioscience |
 Department of Clinical Epidemiology, Biostatistics and Bioinformatics |
 Academic Medical Center |
 University of Amsterdam |
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The Bioinformatics Laboratory pursues three lines of research in areas important for the AMC. This research is generally implemented with groups within and outside the AMC. Systems Genomics aims at the analysis and interpretation of genome-wide omics data in the context of biological networks. Semantic Biosystems focusses on the use of semantic web technologies for the organisation and integration of biomedical data, information and knowledge. Finally, e-Bioscience develops and applies a Grid middleware infrastructure to facilitate distributed and multi-disciplinary collaborations to advance life sciences.
Systems biology Results from this research will largely facilitate systems biology research (which is a AMC spearhead). For example, Systems Genomics contributes to the reconstruction, analysis and interpretation of biological networks. The biomedical knowledge bases developed within Semantic Biosystems organize biological and clinical information, including high-quality definition of pathways and their relation to specific disorders, which will serve as input of mathematical modeling and simulation. Finally, e-Bioscience will provide the data- and computatinal (Grid) infrastructure that is necessary for systems biology. Synergy We also aim to maximize synergy between these research lines and other activities of the lab. For example, the analysis and comparison of biological pathway databases with Systems Genomics provides important information for the development of biomedical knowledgebases with Semantic Biosystems. The infrastructure developed in e-Bioscience is currently used for the analysis of next-generation sequence data. |
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Topic revision: r11 - 2010-02-01 - 08:32:15 - PerryMoerland
BioLab
Systems genomics
BioLab |
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